TY - JOUR A2 - 门多萨 - 迪亚兹，吉列尔莫AU - 马球塞龙，多利安PY - 2019 DA - 2019年7月1日TI - 铜（II）和Ni（II）配合物的新三齿NNS缩氨基硫脲的合成，表征，DNA相互作用，与抗菌活性SP - 3520837 VL - 2019 AB - 本文报道的合成和铜（II）和镍（II）配合物具有三齿配体缩氨基硫脲的详细表征 H ₂ L1和 H ₂ L2由2- acetylpyrazine衍生。配体及其金属配合物，其特征在于不同的物理化学技术，包括元素和热重分析;紫外 - 可见光，红外，¹H-NMR，和¹³C-NMR光谱;摩尔电导测量;和质谱分析。的晶体结构 H ₂ L1配体通过单晶X射线衍射研究确定。光谱数据表明，该缩氨基硫脲的行为作为NNS三齿配体通过偶氮甲碱基和吡嗪环和硫代酰胺基团的硫原子的氮原子。Elemental and thermal analyses indicated that the obtained metal complexes had a 1 : 1 stoichiometry (metal-ligand). The interactions between these complexes and calf thymus DNA (CT-DNA) were studied by electronic absorption and viscosity measurements. The activities of these compounds against oxidative DNA cleavage were examined by agarose gel electrophoresis. Cu(II) and Ni(II) complexes can wind DNA strands through groove interactions and promote strand breakage of the plasmid pmCherry under oxidative stress conditions. Moreover, all the complexes could interact more strongly with DNA than could with the free ligands. Finally, the antibacterial activities of the ligands and their complexes were determined by 体外对革兰氏阳性细菌菌株测试（ 金黄色葡萄球菌ATCC 25923， 单增李斯特菌ATCC 19115，和 蜡样芽孢杆菌ATCC 10876）和革兰氏阴性细菌菌株（ 大肠杆菌ATCC 25922， 鼠伤寒沙门氏菌ATCC 14028，和 肺炎克雷伯菌使用微量肉汤稀释法ATCC BAA-2146）。金属配合物表现出比对一些微生物的前体配体更大的抗微生物活性。SN - 1565-3633 UR - https://doi.org/10.1155/2019/3520837 DO - 10.1155 /三百五十二万○八百三十七分之二千○一十九JF - 生物无机化学及应用PB - Hindawi出版KW - ER -