TY -的A2 -卡斯泰利,洛里AU -风扇,Yongzhao盟——香港,小杨盟——刘,库恩盟——吴,郝PY - 2022 DA - 2022/09/13 TI -运动对纹状体多巴胺水平和焦虑行为在雄性老鼠2-VO脑缺血SP - 2243717六世- 2022 AB -本研究的目的是探讨自愿轮纹状体多巴胺的水平上运行的影响和与全球脑缺血大鼠的焦虑行为。男性Sprague-Dawley老鼠签约在这项研究和后随机分为4组:对照组(C组),虚假的组(S组),缺血组(I组)和前3周锻炼身体缺血组(3 ri组)。3 ri组的老鼠被放置在一个自愿转轮三个星期去锻炼。然后,老鼠在我和3 ri组收到双边颈动脉结扎(2-VO)操作。C和S组没有自愿跑步锻炼和双边颈总动脉(S组暴露不结扎。使用体内微量透析可把时程延长结合高效液相色谱法(HPLC)和电化学检测确定纹状体中多巴胺的水平。高架迷宫(EPM)和开放的领域(的)被用来测试焦虑状态在24小时和7天之后2-VO脑缺血。同时,步态和运动协调评估进行了消除非特异性的影响电动机的问题。结果表明,脑缺血煽动的增加纹状体多巴胺在我组大鼠急性脑缺血。你自愿轮运行显著增强纹状体多巴胺在缺血和阻碍进一步增加多巴胺在3 ri组大鼠急性脑缺血。 At 24 hours after ischemia, striatal dopamine returned to pre-ischemic levels in 3RI group. Striatal dopamine in I group were less than pre-ischemic levels at 7 days. Behavioral data indicated that 3-week voluntary wheel running promoted recovery of anxiety-like behavior and gait were not affected by 2-VO cerebral ischemia at 24 hours post-ischemia rats. Therefore, it can be concluded that 3-week physical exercise significantly increased the striatal dopamine and improved anxiety-like behavior by inhibiting the increase of dopamine during acute cerebral ischemia and suppressing the decrease of dopamine after 24 hours and 7 days cerebral ischemia. SN - 0953-4180 UR - https://doi.org/10.1155/2022/2243717 DO - 10.1155/2022/2243717 JF - Behavioural Neurology PB - Hindawi KW - ER -