TY - JOUR A2 - Luchinat, Claudio AU - Paschoal, André Monteiro AU - Paiva, Fernando Fernandes AU - Leoni，SP - 5040465 VL - 2019 AB -动脉自旋标记(Arterial Spin Labeling, ASL)是一种基于mri的无创测量脑血流(CBF)的方法。最近，当CBF波动来自于脑组织中的毛细血管时，ASL作为功能工具的研究开始出现，与基于血氧合水平依赖(BOLD)对比的标准功能MRI方法相比，ASL具有更大的空间特异性反应。尽管BOLD效应可以用来研究脑功能，但如果要量化CBF，这种效应被认为是一种污染，如果在图像采集中使用短TE值，这种污染会更小。一种同时提供CBF和功能信息的方法是使用双回波ASL (DE-ASL)读出。我们的目的是评估DE-ASL提供的有关CBF量化和运动任务功能连通性的信息。20名健康受试者(年龄32.4±10.2岁，13名男性)通过3T扫描仪获得假连续肌萎缩侧索硬化症。我们分析了TE对CBF和同期BOLD (cc-BOLD)时间序列提供的CBF值和脑连通性的影响。通过一般线性模型和独立成分分析得到脑网络。连接矩阵使用二元相关(Fisher Z值)生成。 No effect of the sequence readout, but significant effect of the TE value, was observed on gray matter CBF values. Motor networks with reduced extension and more connections with important regions for brain integration were observed for CBF data acquired with short TE, proving its higher spatial specificity. Therefore, it was possible to use a dual-echo readout provided by a standard commercial ASL pulse sequence to obtain reliable quantitative CBF values and functional information simultaneously. SN - 1546-6086 UR - https://doi.org/10.1155/2019/5040465 DO - 10.1155/2019/5040465 JF - Concepts in Magnetic Resonance Part A PB - Hindawi KW - ER -