TY - JOUR A2 - Taliani，凯莱AU - Esperti，肖恩AU - Stoelting，奥斯汀AU - 曼加诺，安德鲁AU - 帕特尔，Dveet AU - 桑斯伯里，吉联盟 - Sherertz，罗伯特PY - 2020 DA - 2020年7月14日TI -假阴性CSF隐球菌抗原与隐球菌gattii脑膜脑炎在美国东南部：病例报告和文献综述SP - 8232178 VL - 2020 AB - 在南卡罗来纳州一名70岁的男性免疫功能在没有局灶性神经功能缺损承认继发精神状态改变和头痛。头颅CT阴性。腰椎穿刺（LP）显示正常葡萄糖，升高蛋白，和淋巴细胞增多。Opening pressure was 15 cm of H20. CSF lateral flow assay was negative for cryptococcal antigen; CSF cultures showed no growth. The patient rapidly improved on acyclovir and was diagnosed with presumed viral meningitis, as viral PCR and fungal culture were pending at time of discharge. The patient’s condition quickly worsened and the patient returned one day later with right arm weakness and dysarthria. Brain MRI revealed T2/flair signal abnormalities in the left frontal lobe with associated parenchymal enhancement. Repeat LP revealed increasing white blood cell count with a worsening lymphocytosis and decreasing glucose, and opening pressure remained normal. CSF fungal culture from the first admission grew 隐球菌gattii和重复CSF隐球菌抗原和培养阳性。该患者开始IV类固醇，感应两性霉素和氟康唑，其次是保持口腔氟康唑。该患者的临床过程是由脑干腔隙性脑梗塞，导致灭亡复杂。我们目前的这种情况下 隐球菌gattii脑膜脑炎突出的危险因素，特点，诊断和治疗在美国东南部的新出现的疾病的挑战。SN - 2090-6625 UR - https://doi.org/10.1155/2020/8232178 DO - 10.1155 /八百二十三万二千一百七十八分之二千○二十〇JF - 病例报告传染病PB - Hindawi出版KW - ER -