TY - JOUR A2 - Shaffrey, Mark E. AU - Alenazy, Leila A. AU - Javed, Muhammad AU - Elsiesy, Hussien AU - Raddaoui, Emad AU - Al-Hamoudi, Waleed K. PY - 2020 DA - 2020/04/131型糖尿病SP - 1294074 VL - 2020 AB -糖原肝病(GH)是1型糖尿病罕见的并发症，导致肝细胞糖原异常积聚。GH的确切机制尚不清楚，但血糖和胰岛素水平的波动在促进糖原积累方面发挥重要作用。我们报告一例16岁女性，诊断为控制不良的1型糖尿病合并肝肿大和肝酶升高。该患者多次因糖尿病酮症酸中毒入院，并有2年前根据血清学和十二指肠活检诊断的乳糜泻。实验室分析结果符合急性肝炎，乳糜泻血清学阳性。其他调查排除了病毒性肝炎、自身免疫性和代谢性肝病。腹部超音波及电脑断层扫描显示肝脏肿大及弥漫脂肪浸润。肝活检显示肝细胞胞浆中存在丰富的糖原。PAS染色强烈阳性，证实GH诊断。 There were no features of autoimmune hepatitis or significant fibrosis. Duodenal biopsy results were consistent with celiac disease. Despite our efforts, which are supported by a multidisciplinary team approach that included a hepatologist, a diabetic educator, a dietitian, and an endocrinologist, we have encountered difficulties in controlling the patient’s diabetes, and she persistently maintains symptomatic hepatomegaly and abnormal liver biochemistry. Given the patient’s age, we assumed that these abnormalities were related to patient noncompliance. In conclusion, GH remains an under-recognized complication of type 1 DM that is potentially reversible with adequate glycemic control. The awareness of GH should prevent diagnostic delay and its implications for management and the outcome. SN - 1687-9627 UR - https://doi.org/10.1155/2020/1294074 DO - 10.1155/2020/1294074 JF - Case Reports in Medicine PB - Hindawi KW - ER -