ty -jour a2 -rivet，dennis J. au -sripad，praveen au-罗森伯格，杰西卡·艾斯（Jessica au） - 布尔斯（Jessica au），布尔斯（Boers），弗兰克·艾尔斯（Frank Au -filss），菲尔斯（Frank au -filss），克里斯蒂安·P·au（Christian P. au） - 加尔迪克斯（Christian P. au），诺伯特·艾伯（Norbert au），诺伯·艾伯（Norbert au） - 兰根（Norbert au），朗格（Langen）-Shah，N。Jon au -Dammers，JürgenPy -2020 DA -2020/03/20 Ti- Zolpidem在创伤性脑损伤后的影响：MEG研究SP -8597062 VL -2020 AB-在过去的二十年来, many studies have shown the paradoxical efficacy of zolpidem, a hypnotic used to induce sleep, in transiently alleviating various disorders of consciousness such as traumatic brain injury (TBI), dystonia, and Parkinson’s disease. The mechanism of action of this effect of zolpidem is of great research interest. In this case study, we use magnetoencephalography (MEG) to investigate a fully conscious, ex-coma patient who suffered from neurological difficulties for a few years due to traumatic brain injury. For a few years after injury, the patient was under medication with zolpidem that drastically improved his symptoms. MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. An increase in power after zolpidem intake was found in the higher beta/lower gamma (20–43 Hz) frequency band. Source level functional connectivity measured using weighted-phase lag index showed changes after zolpidem intake. Stronger connectivity between left frontal and temporal brain regions was observed. We report that zolpidem induces a change in MEG resting power and functional connectivity in the patient. MEG is an informative and sensitive tool to detect changes in brain activity for TBI. SN - 2090-6668 UR - https://doi.org/10.1155/2020/8597062 DO - 10.1155/2020/8597062 JF - Case Reports in Neurological Medicine PB - Hindawi KW - ER -