TY - JOUR A2 - Cheng, Shi AU - Wang, Xianghe AU - Ning, Jiaxu AU - Jiang, Yueqiu AU - Liu, Ruhui AU - Zhang, Xinyuan AU - Wu, Jiaxuan PY - 2023 DA - 2023/04/18 TI - A Degenerate Primer Design Method Based on Ant Colony Optimization SP - 8679509 VL - 2023 AB - For the existed biological degenerate primer design problem, a solution method based on an ant colony optimization algorithm is proposed, in which an optimization model considers primer coverage as well as degeneracy while allowing for a small number of base mismatches.算法使用构造图模型充分使用迭代最优路径优化过程动态变化信息,加强探索新路径phromone并选择满足约束条件的素数脱氧核糖核酸模板序列匹配实验结果显示,由拟议算法设计退化素数优于现有方法SN-1026-0226UR-https://doi.org/101155/2023/869509DO-10.1155/2023/869509JF-自然与社会分辨动态-HindawiKW-ER-