TY - JOUR A2 - Smereka，亚采AU - 哈桑，Shumaila AU - 沙里，Aswin AU - Ganau，马里奥AU - UFF，克里斯PY - 2019 DA - 2019年10月31日TI - 定义新的研究问题和议定书的场创伤性脑损伤，通过公众参与：初步结果与文献复习SP的 - 9101235 VL - 2019 AB - 创伤性脑损伤（TBI）是在40岁以下年龄组的死亡和残疾的最常见原因。收入和医疗保健带来了巨大的负担，家庭，社会，社会服务，医疗保健和损失的财务费用，其费用估计为£1英镑十亿每年（约脑损伤（在线））。目前，我们还缺乏对TBI的病理生理有充分的认识，和生物标志物代表了突破性发现的下一个前沿领域。不幸的是，许多原则限制了其广泛应用。脑组织取样是在神经肿瘤学诊断的支柱;下面的这条道路上，我们推测，信息直接从住院的脑外伤患者获得可与TBI患者结果数据相关的神经组织样本收集，使早期，准确，更全面的病理分类，意图指导治疗和未来研究。我们建议组织取样的各种方法在伺机时间：两种方法依赖于正在采取专门的样品;余量依赖于否则将被丢弃的组织。 To gauge acceptance of this, and as per the guidelines set out by the National Research Ethics Service, we conducted a survey of TBI and non-TBI patients admitted to our Trauma ward and their families. 100 responses were collected between December 2017 and July 2018, incorporating two redesigns in response to patient feedback. 75.0% of respondents said that they would consent to a brain biopsy performed at the time of insertion of an intracranial pressure (ICP) bolt. 7.0% replied negatively and 18.0% did not know. 70.0% would consent to insertion of a jugular bulb catheter to obtain paired intracranial venous samples and peripheral samples for analysis of biomarkers. Over 94.0% would consent to neural tissue from ICP probes, external ventricular drains (EVD), and lumbar drains (LD) to be salvaged, and 95.0% would consent to intraoperative samples for further analysis. SN - 2090-2840 UR - https://doi.org/10.1155/2019/9101235 DO - 10.1155/2019/9101235 JF - Emergency Medicine International PB - Hindawi KW - ER -