TY - JOUR A2 - 布拉姆霍尔，西蒙AU - 丹麦，Lubna AU - 西迪克，Riffat AU - 汗，萨尔瓦特AU - Taneez，Mehwish AU - 汗，曼苏尔AU - 桑德，内容Marva PY - 2020 DA - 2020年1月23日TI -小鼠SP西咪替丁和维拉帕米对对乙酰氨基酚诱导的肝脏毒性的保护作用的对比研究 - 9185361 VL - 2020 AB - 对乙酰氨基酚，化学上被称为对乙酰氨基酚，如果采取在较高剂量具有肝毒性的潜力。通过抑制cytochromal酶和降低了生产的毒性代谢物的可以减少的肝脏毒性潜力，同时维拉帕米可以通过维持钙稳态作为保肝作用西咪替丁。本研究中，研究了西咪替丁和维拉帕米的保肝活性抵抗由扑热息痛诱导的毒性。In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity. SN - 2090-3448 UR - https://doi.org/10.1155/2020/9185361 DO - 10.1155/2020/9185361 JF - International Journal of Hepatology PB - Hindawi KW - ER -