TY - JOUR A2 - Slomiany, B. L. AU - Akhmaltdinova, L. AU - Sirota, V. AU - Zhumaliyeva, V. AU - Babenko, D. AU - Kadyrova, I. AU - Tauesheva, Z. AU - Taizhanova, D. AU - Ibraeva, A. AU - Maratkyzy, M. AU - Turmukhambetova, A. PY - 2020 DA - 2020/09/08 TI - Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population SP - 9476326 VL - 2020 AB - Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation. The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β（TGF），肿瘤坏死因子（TNF），与相关的凋亡诱导配体（TRAP）和编程死亡配体1（PD-L1）。我们的研究数据表明，大多数基本的促炎细胞因子涉及系统过程，其水平不依赖于组织分化的水平。血清PD-L1已经显示为肿瘤生长的有希望的标志物，这取决于分化程度。SN - 2090-8040 UR - HTTPS://Doi.org/10.1155/2020/9476326 Do - 10.1155 / 2020/9476326 JF - 国际炎症PB - Hindawi KW - ER -