TY - Jour A2 - Santacroce,Luigi Au - Zahedani,Shahram Shahraki Au - Tahmasebi,Hamed Au - Jahantigh,Mojdeh Py - 2021 Da - 2021_05/21 - 毒力因子和临床中的毒力因子和流出泵基因的共存假单胞菌铜绿假单胞菌:伊朗SP-5557361 VL - 2021 AB的生物膜形成菌株分析 -
背景。生物膜形成和流出泵(EPS)相关在致病性和抗生素抗性中起着关键作用
假单胞菌铜绿假单胞菌。本研究中,生物膜形成和EP在临床分离株中的协作作用
P.铜绿假单胞菌研究了感染。
方法。八十六(86)
P.铜绿假单胞菌从不同的临床标本中收集分离物,并使用不同的生化试验证实。通过使用晶体紫度测定来研究生物膜的形成。此外,通过PCR方法鉴定EP基因。
结果。基于结果,耐庆大霉素(
N = 50, 66.29%) and ciprofloxacin-resistant (
N = 61, 69.66%) strains were the most frequent and colistin (
N = 1, 1.12%) and ceftazidime (
N = 12, 7.86%) resistant strains were the least prevalent. Furthermore, 22 isolates (31.42%) were MDR, and 11 isolates (12.35%) were XDR strains. Also, 19 isolates (22.47%) were classified as strong biofilm, 29
孤立(21.34%)作为中等生物膜,3(11.23%)分离为弱生物膜生产商。EP基因的分布如下:
梅克萨(
N = 44, 34.83%),
MEXB.(
N = 33, 32.58%),
OPRM.(
N = 59, 29.21%),
ophd.(
N = 61, 30.33%),
Teta.(
N = 22, 25.58%),
十四角(
N = 19, 22.09%), and
emre.(
N = 21, 24.41%). However, there was a strong significant association between biofilm formation and EPs in
P. eruginosa。结论。在这项研究中,我们建议存在多药电阻流出泵,MEXEF-OPRN,显着减少
P.铜绿假单胞菌致病性。相比之下,Mexab-oprm和Mexcd-oprj泵的存在并不影响毒力。SN - 1687-918X UR - HTTPS://Doi.org/10.1155/2021/5557361 Do - 10.1155 / 2021/5557361 JF - 国际微生物学杂志PB - Hindawi Kw - ER -