国际风湿病学杂志

骨质流失是类风湿性关节炎的出现关节外表现之一。TNF-αα是主要的炎性细胞因子，可以直接增加骨吸收。然而，它在骨形成中的作用仍然是未知的，特别是有关分泌型卷曲相关蛋白1（SFRP-1），成骨细胞抑制剂。本研究探讨肿瘤坏死因子之间的相关性α和SFRP-1，与骨翻转标记（CTX和P1NP）。这与38名受试者绝经前女性RA患者的剖研究。这项研究发现，患者60.6％为缓解或低疾病活动。TNF-α的中位数αwas 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-αand P1NP ( , ),也SFRP-1和P1NP（间 ; ).A low level of TNF-, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.

阅读全文

原发性系统性血管炎是罕见的疾病同样可以表现更常遇到的条件。根据受影响的容器（大血管，介质的容器中，或小血管）的大小，不同的血管炎模拟物必须加以考虑。建立脉管炎模仿的正确的诊断会避免不必要的免疫抑制治疗。

阅读全文

Mixed connective tissue disease (MCTD) was initially described as a chronic immune-mediated disease with overlapping features of systemic lupus erythematosus, scleroderma, and polymyositis. We conducted a cross-sectional study to describe the clinical and immunological profile of patients with MCTD and to compare the four diagnostic criteria, namely, Sharp, Kasukawa, Alarcón-Segovia, and Khan criteria. A total of 291 patients who were admitted from June 2007 to June 2017 and fulfilled the inclusion criteria were included in the study. A clinical diagnosis of MCTD was made in 111 patients, of whom 103 (92.8%) were women. The mean age at presentation was 39.3 years ( ).The most common organ systems that were involved were musculoskeletal system (95.5%), skin and mucosa (78.4%), and the gastrointestinal and hepatobiliary systems (56%). The maximum sensitivity was for the Kasukawa criteria with a sensitivity of 77.5% (95% CI 68.4-84.6) and specificity of 92.2% (95% CI 87-95.5). The Kahn criteria and Alarcón-Segovia criteria had the maximum specificity; the Alarcón-Segovia criteria had a sensitivity of 69.4% (95% CI 59.8-77.6) and a specificity of 99.4% (95% CI 96.5-99.9), while the Kahn criteria had a sensitivity of 52.3% (95% CI 42.6-61.7) and a specificity of 99.4% (95% CI 96.5-99.9). The sensitivity and specificity of Sharp criteria were 57.7% (95% CI 47.9-66.87) and 90% (95% CI 84.4-93.8), respectively.

阅读全文

Background。Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which can cause cartilage and bone damages as well as pain and disability. In order to prevent disease progression, reduce pain, and major symptoms of RA, one good strategy consists in targeting proinflammatory cytokines that have the key role in the vicious circle of synovial inflammation and pain. The micro-immunotherapy medicine (MIM) 2LARTH® targets cytokines involved in inflammation.Aim。该研究的目的是比较，车辆在以评价MIM的效果体内model of RA, induced in mice after immunization with articular bovine type II collagen.方法。Vehicle and MIM were dissolved in pure water (1 capsule in 100 ml) and 100 μL为灌胃每天给药14天。为了评价关节炎的严重程度，确定手腕和脚踝的厚度，爪水肿进行测定，并建立从0临床评分为4。另外，通过进行组织学分析。为了评估全身性炎症，IL-1的循环水平β和TNF-αwere measured by ELISA.结果。Ankle thickness was found to be significantly reduced in MIM-treated mice compared to vehicle-treated mice ( )并与未经处理的我（ ).爪水肿减少，以及临床评分与媒介物处理的小鼠和未经处理的CIA小鼠（比较归因于MIM处理的小鼠 ).In line with these results, histological analysis confirmed that MIM reduced inflammation and joint destruction in comparison to controls. No significant changes were found in plasmatic IL-1βCIA和对照组之间的水平，而TNF-α的水平αsignificantly increased in the CIA group, and were lowered in MIM-treated mice (对车辆和对CIA）。结论。结果表明，所测试的药物减少了在CIA模型炎症，组织学，和RA的临床症状。

阅读全文

针对本回顾性队列研究，以评估类风湿关节炎（RA）的出席克利夫兰诊所阿布扎比，中东的大型三级医疗中心的阿联酋患者人口统计学和临床​​特征。在这项研究中，414名阿联酋RA患者在3年的时间从​​2015年4至4月2018年所有患者符合2010年RA ACR / EULAR标准，并进行了评估人口和临床特征进行了评价。在我国人口的队列估计RA患病率为2.72％。Females showed predominance (80%) with a higher body mass index (31.4 ± 6.61, )compared to males (28.8 ± 6.03, ).观察到的最常见的合并症是血脂异常（43.5％），其次是高血压（37.9％），糖尿病（34.5％），和胃食管反流病（33.1％）。干眼症是最常见的关节外表现。类风湿因子和抗瓜氨酸肽在63.3％和41.5％的患者，分别进行检测，而无论是在33.3％的患者存在。甲氨蝶呤，阿达木单抗，利妥昔单抗是最常见的处方疾病改性剂。在这项研究中，我们描述病情特点所特有的阿拉伯联合酋长国（UAE）的患者，并表明RA具有显著的疾病负担。我们的研究结果强调有必要对RA国家登记册，以提高护理这些病人在阿联酋的质量。

阅读全文

Background。的性质和系统性红斑狼疮（SLE）胃粘膜（GM）损伤和抗磷脂综合征（APS）速率仍然是未解决的问题之一。目的。To define the role of幽门螺旋杆菌和药物的开发通用的系统性红斑狼疮and APS.方法。一项研究对85例SLE和APS进行。所有患者均接受胃镜与胃体和胃窦粘膜有针对性的活检。的存在幽门螺旋杆菌in the gastric biopsy specimens was determined using polymerase chain reaction.结果。Endoscopic examination revealed that the patients with SLE and APS on admission had the following GM changes: antral gastritis (82.4%), erosions (24.7%), hemorrhages (8.2%), and pangastritis (8.2%). SLE and APS patients showed no direct correlation between the found GM damages and the presence of幽门螺旋杆菌。使用糖皮质激素，低剂量乙酰水杨酸，非甾体抗炎药，抗凝血剂和在SLE和APS患者伴随GM损坏。结论。There was no evidence of the role of幽门螺旋杆菌在SLE和APS患者GM损坏。更频繁的检测幽门螺旋杆菌在抗凝血剂或观察到的低剂量乙酰水杨酸的用户比在糖皮质激素和非甾体抗炎药的。

阅读全文