TY - JOUR A2 - Curley, Steven AU - El Otmani, Ihsane AU - El Agy, Fatima AU - El Abkari, Mohammed AU - Hassani, Karim Ibn Majdoub AU - Mazaz, Khalid AU - Benjelloun, El Bachir AU - Taleb, Khalid AitAU - Bouhafa, Touria AU - Benbrahim, Zineb AU - Ibrahimi, Sidi Adil AU - Chbani, Laila PY - 2020 DA - 2020/01/06 TI - The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer SP - 8406045 VL - 2020 AB - Prognosis for patients with locally advanced rectal cancer remains controversial. The purpose of this study was to elucidate possible association between therapeutic effect on lymph nodes (LNs) and patient prognosis. Overall, 149 patients with rectal cancer received preoperative radiotherapy in concomitance with chemotherapy or exclusive radiotherapy before rectal excision. Microscopic examination of formalin-fixed lymph nodes was assessed for therapeutic effect. The establishment of groups combined reaction tissue types of fibrosis, colloid, and necrosis after neoadjuvant treatment was assigned. The average age was 56.38 years, ranged between 22 and 88 years, 53% were female, and 47% were men, with a sex ratio of 1 : 12. In the present study, we noticed that after a median follow-up time of 40.67 months (0–83; SD: 21.1), overall survival was statistically significant depending on age groups. Kaplan–Meier analysis showed significant differences in the rate of patients with an age under 65 years (70.64%) versus those with an age over 85 years (36.5%) ( p < 0.001 ）。此外，根据由0TE（无治疗效应），C+（仅存在胶体效应），F+（仅存在纤维化组织）和ME+（2或3种治疗类型的混合物）组成的治疗效应组，其OS具有统计学意义。效果）组。确实，我们观察到ME+组的OS率明显更高（86％），而LNS组的OS率无治疗效果（57％）（57％）（57％）（ p = 0.028 ）。此外，在LNS上存在纤维化与新辅助治疗的完成和手术之间存在显着关联。我们的研究表明，可以根据肿瘤对淋巴结的最佳病理作用预测最好的患者预后，并且延迟手术超过8周以使新辅助治疗完成可改善对LNS的治疗反应。SN -2090-1402 UR -https：//doi.org/10.1155/2020/8406045 DO -10.1155/2020/8406045 JF-国际手术肿瘤学杂志PB- Hindawi KW -ER- ER-