TY - JUR A2 - MUSIALEK，PIOTR AU - Keulards，DaniëlleC.J.Au - el Farissi，Mohamed Au - Tonino，Pim。A. L AU - Teeuwen，Koen Au - Vlaar，Pieter-Jan Au - Van Hagen，Eduard Au - Wijnbergen，Inge。F. AU - de Vos, Annemiek AU - Brueren, Guus R. G. AU - van’t Veer, Marcel AU - Pijls, Nico H. J. PY - 2020 DA - 2020/11/18 TI - Thermodilution-Based Invasive Assessment of Absolute Coronary Blood Flow and Microvascular Resistance: Quantification of Microvascular (Dys)Function? SP - 5024971 VL - 2020 AB - During the last two decades, there has been a sharp increase in both interest and knowledge about the coronary microcirculation. Since these small vessels are not visible by the human eye, physiologic measurements should be used to characterize their function. The invasive methods presently used (coronary flow reserve (CFR) and index of microvascular resistance (IMR)) are operator-dependent and mandate the use of adenosine to induce hyperemia. In recent years, a new thermodilution-based method for measurement of absolute coronary blood flow and microvascular resistance has been proposed and initial procedural problems have been overcome. Presently, the technique is easy to perform using the Rayflow infusion catheter and the Coroventis software. The method is accurate, reproducible, and completely operator-independent. This method has been validated noninvasively against the current golden standard for flow assessment: Positron Emission Tomography-Computed Tomography (PET-CT). In addition, absolute flow and resistance measurements have proved to be safe, both periprocedurally and at long-term follow-up. With an increasing number of studies being performed, this method has great potential for better understanding and quantification of microvascular disease. SN - 0896-4327 UR - https://doi.org/10.1155/2020/5024971 DO - 10.1155/2020/5024971 JF - Journal of Interventional Cardiology PB - Hindawi KW - ER -