TY - Jour A2 - Campbell,Charles Larry Au - Vanhala,Mauno Au - Hannu,Kautiainen Au - Esko,Kumpusalo Py - 2008 Da - 2008/12/30 Ti - Proinflamation和高血压:一名以人口为基础的研究SP - 619704 VL -2008年AB - 有证据表明促炎可能与高血压(HT)的发育联系起来。我们检查了白细胞介素-1β(IL-1)的关联(IL-1
β
)和未来血压(BP)和HT发生的白细胞介素1-受体拮抗剂(IL-1RA)(
BP.
≥
140.
/
90.
mmHg, or antihypertensive drug) in a population-based prospective study. Our study consisted of 396 (147 men and 249 women) middle-aged, baseline apparently healthy, normotensive subjects participating in a 6.5-year follow-up study. Subjects with high-sensitivity CRP (hs-
CRP)
<
10.
mg/L were excluded at the initial visit. At follow-up, the occurrence of HT was 32%. The levels of baseline IL-1
β
在随访期间开发HT的科目而不是对没有(IL-1的人)显着更高
β
;0.67
±
0.62 pg / ml与0.56
±
0.32 pg / ml,
P.
=
.020
和il-1ra;184.
±
132 pg / ml与154
±
89 pg / ml,
P.
=
.007
)。调整年龄,随访时间,性别,基线收缩型BP和BMI,我们的结果证实了统计上重要的(
P.
=
.036
)IL-1四分位数之间的线性关联
β
研究期间收缩型BP的变化。调整年龄,随访时间,性别和BMI后,我们的结果还显示了事件HT和IL-1RA的四分位数之间的线性关联。(
P.
=
.026
)。这些结果提供了促释放的证据可以先于BP升降和HT。SN - 0962-9351 UR - https://doi.org/10.1155/2008/619704 Do - 10.1155 / 2008/619704 JF - 炎症PB的介质 - Hindwi Publishing Corporation KW - ER -