TY - JOUR A2 - Lee, Kang-Yun AU - Ma, Lijie AU - Zhao, Yilin AU - Wang, Ruixuan AU - Chen, Tingting AU - Li, Wangping AU - Nan, Yandong AU - Liu, Xueying AU - Jin, Faguang PY - 2015 DA - 2015/11/16 TI - 3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway SP - 143074 VL - 2015 AB - The aim of the present research was to investigate the protecting effects of 3,5,4′-tri-O-acetylresveratrol (AC-Rsv) on LPS-induced acute respiratory distress syndrome (ARDS).肺损伤通过组织学检验、湿干权比和细胞计数和支气管熔液蛋白含量评价点火由MPO活动评估 并分解肺细胞结果表明AC-Rsv显著降低了鼠用LPS刺激的死亡率。AC-Rsv减慢LPS诱发的语理变化预处理、松散肺水肿、减少血液流出并抑制肺部MPO活动况且AC-Rsv和Rsv处理减少了TNF分解 α IL-6和IL-1 辰族 肺部和NR8383细胞深入探索发现AC-Rsv和Rsv处理解排LPS诱发SIRT1表达式抑制并限制LPS对MAPKs和NF- 百货公司 B激活体外和体外更重要的是,Vivo结果还显示,当SIRT1受EX527阻塞时,Rsv对LPS诱发炎的保护效果将被中和综合这些结果显示AC-Rsv保护肺组织避免LPS诱发ARDS通过p38MAPK/SIRT1路径减少炎SN-0962-9351UR-https://doi.org/101155/2015/143074DO-10/1155/2015/143074JF-InflamationPB-Hindawi出版公司KW-ER-