TY - JOUR A2 - Giovarelli, Mirella AU - Simion, Viorel AU - Constantinescu, Cristina Ana AU - Stan, Daniela AU - Deleanu, Mariana AU - Tucureanu, Monica Madalina AU - Butoi, Elena AU - Manduteanu, Ileana AU - Simionescu, Maya AU - Calin, Manuela PY - 2016 DA - 2016/09/14 TI - P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation SP - 1625149 VL - 2016 AB - Inflammation is a common process associated with numerous vascular pathologies.我们假设通过联结高亲和度P-选择到德西米索内负脂纳米化将高度增强对活性内分泌细胞的具体绑定并减少细胞激活开发并定性向P选择并监控反炎效果 试管内 eccedEC(EA.hy926单元格) 维沃 鼠标快速发炎模型C57BL/6鼠标静脉管PLN-Dex具体绑定到激活EC表面后,EC高效内化并减少寄生性基因表达方式,从而防止单细胞粘附和移入/通传激活ECPLN-Dex静脉注射急症小鼠,肺中高密度积聚(与非目标纳米素相比)并显著降低IL-1等关键阻发性细胞素 辰族 IL-6和MCP-1归根结底,新开发纳米化PLN-Dex功能化 试管内 并 维沃 选择性地减少ium激活并随之单细胞渗透并显著减少肺炎,用鼠标急发炎模型SN-0962-9351UR-https://doi.org/101155/2016/161615149DO-10.1155/2016/161616161615149JF-InflamationPB-Hindawi出版公司KW-ER-