TY - JOUR A2 - Gu, Bingjie AU - Zhang, Jianye AU - Du, Xiaoping AU - Wang, Hui AU - Bao, Yatao AU - Lian, Meng AU - Xu, Zhiwei AU - Ju, Jiyu PY - 2021 DA - 2021/10/21 TI - A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse SP - 8175863 VL - 2021 AB - A variant of somatic nuclear autoantigenic sperm protein (sNASP) was identified from the murine lupus susceptibility locus Sle2c1 by whole exome sequencing (WES).先前研究显示变异SNASP可协同Fas ^四月突变加剧自免并加重端机炎在当前研究中, sNASP突变引入Sle1.Ya小鼠检测它是否与Sle1或Yaaloci产生协同效果与Sle1.Ya小鼠Sle1.Ya Δ sNASP鼠标显示放大淋巴结点数、加重肾炎并缩短生存时间比例CD3 ⁺T细胞激活CD19 ⁺CD86 ⁺B单元、pleen和lymph节点中的Th1单元和Sle1.Yaa中th17节点中的th17单元 Δ sNASP小鼠比Sle1.Ya小鼠增加水平IFN- 南锥体 和TNF- α 血清Sle1.Ya Δ sNASP小鼠比Sle1.Ya小鼠高以上结果显示变异 sNASP可与不同的lupus易感基因交互并推广系统lupusrythematosus的疾病过程SN-0962-9351UR-https://doi.org/101155/2021/8175863DO-10.1155/2021/875863JF-Inflamation PB-HindawiKW-ER-