ty -jour a2 -Ali Sheikh，MD Sayed Au -Deng，Lin Au -Mi -Mi，Jinglin Au -Ruan -Ruan，Xiaolan au -Zhang -Zhang，Guozhen au -Pan，Yufei au -Wang -Wang，Rensheng Py -20222 DA -2022/2022/10/17/17/17/17/17/17/17/17/17/17TI-通过全面的生物信息学方法SP -4007469 VL -2022 AB-头颈癌是全球第六大癌症，大多数亚型是全球第六大癌症，鉴定和分析了头颈鳞状细胞癌中与衰老相关的基因的鉴定和分析。头颈部鳞状细胞癌（HNSCC）。已经证实了与细胞衰老相关的基因在癌症中起关键作用，并且有可能成为癌症的预后生物标志物。HNSCC样品和表达数据的临床信息是从公共数据库中获取的。与细胞衰老相关的基因的表达谱用于通过共识聚类鉴定分子亚型。为了筛选不同亚型之间差异表达的基因（DEG），进行了差分分析。我们使用单变量COX回归来识别预后的DEG，并进行了最少的绝对收缩和选择算子（LASSO），以优化和构建预后模型。Cibersort，估计和潮汐工具用于估计免疫特征。基于细胞衰老相关基因建立了四个分子亚型。 Differential prognosis was observed among different subtypes with C4 having the longest overall survival and C1 having the worst prognosis. C4 subtype also showed the highest immune infiltration. We screened a total of eight cellular senescence prognosis-related genes and established a cellular senescence-related signature score (CSRS.Score) that could stratify samples into high-CSRS.Score and low-CSRS.Score groups. The high-CSRS.Score group had worse prognosis, lower immune infiltration, and lower response to immunotherapy. We further improved the prognostic model and survival prediction by combining CSRS.Score with clinicopathological features using a decision tree model, which had high predictive accuracy and survival prediction. This study demonstrated an important role of cellular senescence in HNSCC. The identified eight cellular senescence-associated genes have the potential to provide ideas for adjuvant treatment and personalized treatment of HNSCC patients. SN - 0962-9351 UR - https://doi.org/10.1155/2022/4007469 DO - 10.1155/2022/4007469 JF - Mediators of Inflammation PB - Hindawi KW - ER -