TY - JOUR A2 -查普曼，C. Andrew AU -张伯伦，索菲E. L. AU -杨，Jian AU -琼斯，罗兰·s·g . PY - 2008 DA - 2008/10/29 TI -门冬氨酸受体亚型在短期可塑性大鼠内嗅皮层SP - 872456六世- 2008 AB -我们曾表明,自发释放的谷氨酸内嗅皮层(EC)是通过激活tonically促进突触前包含NR2B的NMDA受体(NMDAr)subunit. Here we show that the same receptors mediate short-term plasticity manifested by frequency-dependent facilitation of evoked glutamate release at these synapses. Whole-cell patch-clamp recordings were made from layer V pyramidal neurones in rat EC slices. Evoked excitatory postsynaptic currents showed strong facilitation at relatively low frequencies (3 Hz) of activation. Facilitation was abolished by an NR2B-selective blocker (Ro 25-6981), but unaffected by NR2A-selective antagonists ( 锌 2 + NVP-AAM077)。相反，这三种拮抗剂的亚单位选择性浓度均可降低突触后nmda介导的反应。研究结果表明，参与V层突触前可塑性的NMDAr仅为NR1/NR2B双异构体，而在突触后可能是NR1/NR2A、NR1/NR2B双异构体和NR1/NR2A/NR2B三异构体的混合物。SN - 2090-5904 UR - https://doi.org/10.1155/2008/872456 DO - 10.1155/2008/872456 JF -神经可塑性