TY - JOUR A2 - 布朗斯坦,杰夫AU - Rafati,阿里AU - Yazdani的,哈哲尔AU - Noorafshan,阿里PY - 2015年DA - 2015年6月8日TI - 吡格列酮改善神经元丢失在大鼠SP铝处理后的Cortex -381934 VL - 2015 AB - 目的是吡格列酮对内侧前额叶皮质(mPFC中)暴露于铝(Al)的大鼠的影响的评价。铝诱导几个大脑区域的结构性变化,包括内侧前额叶皮质。吡格列酮是过氧化物酶体增殖物激活受体γ的激动剂。Male rats were randomly assigned to control, Al-treated (10 mg/kg/day), and Al + PIO-treated groups (Al+ 40 mg/kg/day). After 56 days, the right mPFCs were removed. Then, the volume of mPFC and its subdivisions, volume of vessels, and total number of neurons and glia were estimated using stereological methods. The results showed 13–38% decrease in the volume of the mPFC and its subdivisions, mainly in the infralimbic region (
P
<
0.02
)。此外,容器的体积的Al-治疗后降低了47%(
P
<
0.02
)。神经元和神经胶质细胞的总数在所述Al-暴露大鼠也减少(40%和25%,RESP)相比于对照的人(
P
<
0.02
)。用Al + PIO动物的处理改善神经元的损失和改善其他参数被视为(
P
<
0.02
)。由此可以得出结论,治疗PIO大鼠能改善在铝处理的动物的内侧前额叶皮质神经元丢失。SN - 2090年至1852年UR - https://doi.org/10.1155/2015/381934 DO - 10.1155 /三十八万一千九百三十四分之二千○一十五JF - 神经学研究国际PB - Hindawi出版公司公司KW - ER -