TY - Jour A2 - Stocchi,Fabrizio Au - Hwynn,Nelson Au - Ul Haq,Ihtsham Au - Malaty,Irene A. Au - Resnick,Andrew S. Au - Dai,Yunfeng Au - Foote,Kelly D. Au - Fernandez,HubertH. Au - Wu,Samuel S. Au - Oyama,Genko Au - Jacobson,Charles E. Au - Kim,Sung K. Au - Okun,Michael S. Py - 2011 DA - 2011/12/19 Ti - 深度影响Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study SP - 507416 VL - 2011 AB - Parkinson’s disease (PD) management has traditionally focused largely on motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are effective treatments for motor symptoms. Nonmotor symptoms (NMSs) may also profoundly affect the quality of life. The purpose of this pilot study was to evaluate NMS changes pre- and post-DBS utilizing two recently developed questionnaires. 方法。NMS-Q(调查问卷)和NMS-S(SCALES)在单侧DBS(STN / GPI靶标)之前/后给予PD患者。 结果。包括十名PD患者(9 Stn植入物,1个GPI植入物)。在前手术前患者中使用NMS-Q的三种最常见的NMS症状是胃肠道(100%),睡眠(100%)和尿(90%)。NMS Sleep Escairore显着降低(-1.6点±1.8, P. = 0.03 )。使用NMS-S前手术前患者中鉴定的三种最常见的NMS症状是胃肠道(90%),情绪(80%)和心血管(80%)。在杂项症状(疼痛,Anosmia,重量变化和出汗)中看到了NMS评分的最大平均下降(-7点±8.7),以及心血管/下降(-1.9, P. = 0.02 )。 结论。在PD的单侧DBS后两个单独的问卷中的非运动症状改善。需要未来的研究来确认这些发现并确定其临床意义,并检查每个问卷/规模的优势/弱点。SN - 2090-8083 UR - https://doi.org/10.4061/2011/507416 Do - 10.4061 / 2011/507416 JF - 帕金森病PB - Sage-Hindawi进入研究KW - ER -