TY - Jour A2 - Jahanshahi，Marjan Au - Maldonado-Naranjo，Andres Au - Koop，Mandy Miller Au - Hogue，Olivia Au - Alberts，Jay Au - Machado，Andre Py - 2019 Da - 2019/04/02 Ti - 运动学指标from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson’s Disease SP - 6850478 VL - 2019 AB - A fundamental challenge in the clinical care of Parkinson disease (PD) is the current dependence on subjective evaluations of tremor and bradykinesia. New technologies offer the ability to evaluate motor deficits using purely objective measures. The aim of this study was to develop and evaluate the efficacy of a wireless stylus (Cleveland Clinic Stylus) with an embedded motion sensor to quantitatively assess tremor and bradykinesia in patients with PD with subthalamic nucleus (STN) deep brain stimulation (DBS). Twenty-one subjects were tested in various on and off DBS conditions while holding the Cleveland Clinic Stylus while at rest, maintaining a postural hold, and during a movement task. Kinematic metrics were calculated from the motion sensor data, including 3D angular velocity and 3D acceleration data, and were compared between the on and off conditions. Generalized estimating equations (GEEs) were used to determine the relationship between kinematic metrics and MDS-Unified Parkinson’s Disease Rating Scale Motor III (UPDRS-III) subscores. Kinematic metrics from the rest and postural tasks were significantly related to the UPDRS-III subscores of tremor ( P. < 0.001 对于所有指标），动作任务的运动学指标与Bradykinesia的UPDRS-III群有关（ P. < 0.001 对于3/7度量）。运动学指标（7/9）显示出刺激设置的显着效果（范围： P. < 0.03 - < 0.0001. ）在三项任务中，表明在这些措施中的DBS显着改善。克利夫兰诊所触控笔提供了震颤和Bradykinesia严重程度的定量运动测量，并检测到这些措施的显着改善来自药物和DBS治疗。这种低成本，易于使用的工具可以提供客观度量，通过提供更可靠和客观评估的运动症状，疾病进展和临床环境中的治疗的影响，改善PD患者的临床护理。SN - 2090-8083 UR - https://doi.org/10.1155/2019/6850478 Do - 10.1155 / 2019/6850478 JF - 帕金森病PB - Hindawi Kw - ER -