TY - Jour A2 - Bodis-Woller，Ivan Au - Taguchi，Soutarou Au - Tanabe，Nachi Au - Niwa，Jun-Ichi Au - Doyu，Manabu Py - 2019 Da - 2019 Da - 2019年DA - 2019年DA - 2019/03/03 Ti - Motor改善相关的区域脑房Blood Flow Changes in Parkinson’s Disease in Response to Antiparkinsonian Drugs SP - 7503230 VL - 2019 AB - Little is known about the relationship between regional cerebral blood flow (rCBF) change and clinical improvement in patients with Parkinson’s disease (PD). Single-photon emission computed tomography (SPECT) measurement of cerebral blood flow allows evaluation of temporal changes in brain function, and using SPECT, we aimed to identify motor improvement-related rCBF changes in response to the administration of antiparkinsonian drugs. Thirty PD patients (16 without dementia; 14 with dementia) were scanned with technetium-99m labeled ethyl cysteinate dimer SPECT and were rated with the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale part III, both before and after a single administration of antiparkinsonian drugs. The SPECT data were processed using Statistical Parametric Mapping 2, the easy Z.-Score成像系统和基于体素的立体定向提取估计。在施用抗原蛋白酶施用后的深脑结构中的RCBF响应往往大于皮质区域中的反应。在这些深脑结构中，RCBF在实质性NIGRA（SN）中增加，横向酸（LG）体，和与药物功效相关的内侧核素（MG）体（ P. < 0.05 ， 分别）。亚组分析表明，无论认知功能如何，MG的电动机改善相关的RCBF变化都是统计学意义的，但在痴呆症的受试者中没有发现LG和Sn的显着变化。总之，我们的SPECT研究明显表现出PD患者的药物驱动的RCBF变化，我们新发现了LG和MG的运动改善相关的RCBF变化。这些结果表明，这些地区的RCBF变化可以被视为临床指标的候选者，用于客观评估疾病进展。此外，专注于LG和MG的功能研究，特别是关于使用视听刺激的疗法，可以带来一些新的线索来解释PD的病理生理学。SN - 2090-8083 UR - https://doi.org/10.1155/2019/7503230 do - 10.1155 / 2019/7503230 jf - 帕金森病pb - hindawikw - er -