TY - JOUR A2 - Teive, Hélio AU - Han, Fei AU - Perrin, Richard J. AU - Wang, Qing AU - Wang, Yong AU - Perlmutter, Joel S. AU - Morris, John C. AU - Benzinger, Tammie L. S. AU - Xu, Jinbin PY - 2019 DA - 2019/07/04 TI - Neuroinflammation and Myelin Status in Alzheimer’s Disease, Parkinson’s Disease, and Normal Aging Brains: A Small Sample Study SP - 7975407 VL - 2019 AB - Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD). Chronic neuroinflammation with sustained activation of microglia and astrocytes may affect white matter tracts and disrupt communication between neurons. Recent studies indicate astrogliosis may inhibit remyelination in demyelinating disorders such as multiple sclerosis. In this study, we investigated the relationship between neuroinflammation and myelin status in postmortem human brain tissue ( N = 15 including 6 AD, 5 PD, and 4 age-matched, neurologically normal controls (NC)). We conducted systematic and quantitative immunohistochemistry for glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule 1 (Iba1), amyloid beta, and highly phosphorylated tau (tauopathy). White matter intactness was evaluated by myelin and axon staining in adjacent brain tissue sections. Eight of 15 cases (4 AD, 3 PD, and 1 NC) showed increased immunoreactivity for microglia and astrocytes in the white matter that connects striatum and cortex. Quantitative analysis of these 8 cases showed a significant negative correlation between GFAP (but not Iba-1) and myelin (but not axon) staining in white matter ( R. ² = 0.78, P. < 0.005. ）。TAU，但不是淀粉样蛋白β斑块，在AD与PD和NC中显着高。在广告案件中，Tau负担随着年龄的增长而增加。这些观察结果表明，白质中的星星胶质菌与AD，Pd和正常衰老中髓鞘的损失有关，并且Tau是AD的有效生物标志物。SN - 2090-8083 UR - https://doi.org/10.1155/2019/7975407 do - 10.1155/2019 / 7975407 jf - 帕金森病pb - hindawikw - er -