ty -jour a2 -tan，英国国王王-Wang，jing au -cao，ruihua au -huang au -huang，tao au -liu -liu，cheng au -fan au -yidong py -2020 da -2020/2020/11/28 ti -ti-with Nigrostriatal Dopaminergic Degeneration in Early and Untreated Patients with Parkinson’s Disease SP - 4981647 VL - 2020 AB - The aim of the present study was to determine the relation between urinary dysfunction and nigrostriatal dopaminergic degeneration in early and untreated Parkinson’s disease (PD). The data were obtained from Parkinson’s Progression Markers Initiative database. Two hundred and seventy-five patients and 149 healthy controls were included in our analysis. Urinary symptoms were evaluated with the Scale for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT). We performed correlation analyses between¹²³I-FP-CIT SPECT成像数据和PD患者和健康对照患者的尿症状严重程度。与健康对照相比，患有PD的早期和未经治疗的患者表现出更严重的尿症状。泌尿症状的严重程度与尾状和壳虫中的多巴胺转运蛋白结合水平显着相关。在控制年龄和性别后，储存症状的严重程度与多巴胺转运蛋白的结合水平显着相关 r = −0.172, p = 0.004 ）。在男性中都观察到了相关性（男性 r = −0.152, p = 0.043 ）和女性患者（ r = −0.217, p = 0.034 ）。在男性或女性患者中，多巴胺转运蛋白结合水平和空隙症状之间没有发现相关性，或者在健康对照中的任何尿症状。较差的储存症状反映了早期和未经治疗的PD中较大的黑质性多巴胺能损失。SN -2090-8083 UR -https：//doi.org/10.1155/2020/4981647 do -10.1155/2020/4981647 JF-帕金森氏病-PB -Hindawi KW- hindawi kw-- er- er-