TY - JOUR A2 - Mirabella, Giovanni AU - Schmidt, Nele AU - Paschen, Laura AU - Witt, Karsten PY - 2020 DA - 2020/11/16 TI - Invalid Self-Assessment of Olfactory Functioning in Parkinson’s Disease Patients May Mislead the Neurologist SP - 7548394 VL - 2020 AB - Olfactory dysfunction (OD) is a prominent nonmotor symptom in Parkinson’s disease (PD), and OD is a supportive diagnostic criterion for PD. Physicians often ask their patients if they have noticed a smell disorder. This study evaluates the diagnostic validity of OD self-assessment in PD. To this end, 64 PD patients and 33 age-matched healthy controls were enrolled in a study assessing subjective and objective olfactory functioning. To examine subjective olfactory abilities, first, patients and controls had to classify their olfactory sense as “impaired” or “unimpaired,” comparable to a realistic situation in an outpatient setting. Second, to evaluate subjective olfactory acuity, a visual analogue scale (VAS) was used. Third, the Sniffin’ Sticks test battery was used as an objective instrument to diagnose OD. Categorical olfactory self-assessment predicts the classification normosmic versus hyposmic based on the global Sniffin’ Sticks score (TDI) with a sensitivity of 0.79 and a specificity of 0.45. TDI correlated significantly with the VAS ( R. = 0.297, P. = 0.017 ）。ROC曲线分析，使用VAS评级作为客观嗅觉的预测器，显示42作为最佳截止得分，曲线下的面积为0.63。这些结果表明，嗅觉自我评估显示出低的精度，并且不适合诊断PD中的气味障碍。客观措施有必要评估临床和研究环境中的嗅觉。SN - 2090-8083 UR - https://doi.org/10.1155/2020/7548394 Do - 10.1155 / 2020/7548394 JF - 帕金森病PB - Hindawi KW - ER -