TY -的A2 -费舍尔,西里尔盟,Yoo ChanghoonU - Kim, Jeong-Eun AU - Yoon, Shin-Kyo AU - Kim, Song Cheol AU - Ahn, Jin-Hee AU - Kim, Tae Won AU - Suh, Cheolwon AU - Lee, Jae-Lyun PY - 2009 DA - 2009/05/20 TI - Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib SP - 360875 VL - 2009 AB - A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angiosarcomas. When sunitinib is administered to patients with angiosarcomas, hematologic abnormalities should be monitored frequently as severe hematologic toxicity may be caused either by sunitinib per se or angiosarcoma. SN - 1357-714X UR - https://doi.org/10.1155/2009/360875 DO - 10.1155/2009/360875 JF - Sarcoma PB - Hindawi Publishing Corporation KW - ER -