Background. Clear cell chondrosarcoma (CCC) represents less than 6% of all chondrosarcomas, and thus, our understanding of this rare entity is limited. Analyzing clinical characteristics and treatment patterns, thus increasing our knowledge, may improve treatment strategy. We review our institutional experience with 15 patients, including one case with dedifferentiation. Methods. A retrospective review was conducted in CCC patients treated at our institution from 1996 to 2015, with at least 2-year follow-up. Descriptive statistics and Kaplan–Meier survival analyses were performed. Results. Of 19 patients identified, 15 patients had at least 2-year follow-up and were included. The median age at diagnosis was 43 years. 80% were male. The most common presenting signs were pain (12 patients; 80%) and fracture (2 patients; 13.3%). The most common site was proximal femur (8 patients; 53%). All patients had MSTS Stage I disease. Primary treatment included wide resection in 10 patients (67%) and intralesional or marginal resection in 5 patients (33%). Three patients died of disease during the study period, 1 with dedifferentiation of recurrent CCC. The median time to death from disease was 15.3 years (95% CI: (14.2; NA)). The median time to either recurrence or death was 7.73 years for patients who had intralesional/marginal resection and 16.44 years for patients with wide resection (HR (wide vs. intralesional/marginal) = 0.21, 95% CI: (0.04; 1.18), ). The median time to recurrence or death was significantly shorter for patients not initially treated at a sarcoma center (). Conclusions. CCC is a rare entity, and our understanding of it is still evolving. We observed a higher recurrence rate for intralesional or marginal resection, and wide resection alone remains the mainstay of treatment. Better outcomes were observed in patients initially treated by trained musculoskeletal oncologists. Due to the propensity of CCC to recur decades after initial resection, lifelong surveillance is recommended.

萨科马

目录

目录

剖腹产Sarcoma国家癌症数据库991名病人的临床特征和结果

清除细胞Chondrosarcoma:15个病人的临床特征和结果

骨形外科剖析

儿科肿瘤学和病理学调查Ewing和Ewing类Sarcoma变量移位:儿童肿瘤学小组报告

KaposiSarcoma与Gout潜在关联:探索式观察研究

诊断特征管理与结果

努力实现日常生活的常态性:对长期临床复发中与异性胃纹理相容的病人进行定性研究

高级Sarcoma中心专家二次咨询案例诊断差异

时间趋势和预测因素 Myxoidliposarcomas总体生存

药法启发Ezrin-Radixin-Moesinphoration

软组织Sarcoma和BoneSarcoma在意大利的流行病分析

Scalp和face系统Angisarcoma比对HDS表层应用器Brachy理疗VMAT

使用Scout计算Tommascripation成像预测路由骨架

Desmoid-Type患者声音评估:两个国家患者健康相关生活质量经验比较

Bone Sarcoma护理跟踪:跨区欧研