TY - JOUR A2 - 支柱,Giora AU - 沃克,麦考AU - 布莱克威尔,雅各布N. AU - 斯塔福德,帕特里克AU - 帕特尔,第AU - Mazimba,苏拉AU - 梅塔,Nishaki AU - 卓,Yeilim AU - Mangrum,迈克尔·AU - 纳扎里安,萨满AU - Bilchick,肯尼斯AU - 权,Younghoon PY - 2020 DA - 2020年2月5日TI - 白天QT常规12导联心电图延长患者重度阻塞性睡眠呼吸暂停SP - 3029836 VL - 2020AB - 背景。阻塞性睡眠呼吸暂停(OSA)已被链接到心脏性猝死(SCD)。延长的QT是一种公认​​的心电图(ECG)链接到SCD风险增加异常心室复极的标记物。我们假设与OSA个人有在白天QT间期更明显异常。 方法。我们回顾连续病人12导联心电图1年内在一个单一的中心谁接受临床指征多导睡眠监测。心脏速率校正的QT间期(QTc)通过OSA严重性类进行比较(正常/轻度: 窒息 - 低通气 指数 AHI < 15 / 小时 ñ = 72 );中度:15-30( ñ = 72 );重度:> 30( ñ = 105 ))调整为身体质量指数,年龄,性别,高血压和心脏衰竭。进一步的评价通过将患者分为严重(执行 AHI > 三十 )和非严重(<30)OSA。Logistic analysis was used to determine association of OSA severity and abnormal QTc (>450/>470 ms for men/women, respectively). 结果。共有249例患者。QTc was similar between the normal/mild and moderate groups, and the overall QTc trend increased across OSA (normal/mild: 435.6 ms; moderate: 431.36; severe: 444.4; p 趋势 = 0.03 )。QT间期异常被发现之间的男性34%,女性患者的31%。Patients with severe OSA had longer QTc compared with normal/mild OSA (mean difference (95% CI): 10.0 ms (0.5, 19.0), p = 0.04 )。When stratified dichotomously (as opposed to three groups), patients with severe OSA again had longer QTc (vs. nonsevere OSA) (444.4 ms vs. 433.48 ms, p = 0.004 )。严重OSA也与异常的QTc(OR(95%CI)相关联:2.68(1.34,5.48), p = 0.006 )。 结论。在睡眠诊所队列中,严重OSA与较高的QTc相关联,并且在临床上的异常的QTc与非严重OSA相比定义。SN - 2090-3545 UR - https://doi.org/10.1155/2020/3029836 DO - 10.1155 /三百○二万九千八百三十六分之二千○二十○JF - 睡眠障碍PB - Hindawi出版KW - ER -