ty -jour a2 -lobetti，remo au -arita，shinji au -arita，noboru au -hikasa，yoshiaki py -2020 da -2020/01/13 ti- eplerenone对血液压力和超声心动图和超声心动膜和血清复杂变量的影响狗：一项试验研究SP -5193856 VL -2020 AB -Eplerenone（EP），醛固酮拮抗剂，据报道在非氨基甲烷物种中产生肾脏和心脏保护作用。但是，尚无有关EP在狗中心血管效应的详细报告。这项研究旨在确定EP对健康狗的超声心动图参数，血压和生化变量的影响。将五只健康的小狗狗随机分裂，并在3剂组中反复使用，并接受2.5、5或10 mg/kg bw bw EP EP OP Q24 h，可容纳4周。在EP给药前，在EP给药后的1、2和4周之前，进行了血清生化测试，血压和多普勒超声心动图测量。用EP的治疗以剂量依赖性的方式降低平均血压，并且显着（但以剂量独立的方式）降低了左心房/主动脉比，早期舒张期经传递流动，早期舒张期经炎性传播流量/舒张期晚期舒张性传播流，早期的峰值速度舒张期早期舒张二尖瓣运动，左心室和右心室TEI指数，中风体积，心输出量和中部心肌速度梯度1至4周后1至4周。EP施用后，早期舒张期经传递流量的减速时间显着增加。在血清生化变量中未观察到显着变化。 The results indicated that EP might reduce preload, thereby decreasing left atrial size. In addition, reduction of left ventricular stiffness may have theoretically taken place but this could not be tested using the present study design. It is suggested that EP administration within the dose range used in this study is safe for administration to healthy dogs. Further studies are needed to explore both safety and efficacy, as well as to seek a recommended dose range of EP treatment in client-owned dogs with heart disease. SN - 2090-8113 UR - https://doi.org/10.1155/2020/5193856 DO - 10.1155/2020/5193856 JF - Veterinary Medicine International PB - Hindawi KW - ER -